NF-?B-IN-5

• Target:

  Others|||Apoptosis|||NF-?B

• Related Pathways:

  Others|||NF-?B|||Apoptosis

• Bioactivity:

  NF-?B-IN-5 (compound 4d) is an orally active NF-?B inhibitor that interacts directly with NF-?B, and exhibits antitumor activity against human cancer cell lines, with IC50 values of 5.35, 2.81, 2.83, 2.02, and 3.90 ?M for HCT116, U87-MG, HepG2, BGC823, and PC9, respectively.

• Smiles:

  C[C@]12[C@@] ([C@@]3 ([C@] (C (=C) C (=O) O3) (CC/C (/C=N/NC (NC4=CC=C (C) C=C4) =O) =C\CC1) [H]) [H]) (O2) [H]

• Molecular Formula:

  C23H27N3O4

• Molecular Weight:

  409.48

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2425675-52-9