NF-κB-IN-14

NF-κB-IN-14

• CAS Number: 3019972-01-8
• UNSPSC Description: NF-κB-IN-14 (compound 5e) significantly inhibits nitric oxide production in LPS-induced macrophages (IC50: 6.4 μM). NF-κB-IN-14 disrupts the TLR4-MyD88 protein interaction, leading to the suppression of the NF-κB signaling pathway suppression. NF-κB-IN-14 reduces ear edema and inflammation in an atopic dermatitis mouse model[1].
• Target Antigen: NF-κB; Toll-like Receptor (TLR)
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;NF-κB
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/nf-κb-in-14.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=CC=C(/C=C/CN2C=NC3=C(Cl)N=C(Cl)N=C23)C=C1
• Molecular Weight: 319.19
• References & Citations: [1]Pham L, et al. Synthesis of 9-Cinnamyl-9H-purine Derivatives as Novel TLR4/MyD88/NF-κB Pathway Inhibitors for Anti-inflammatory Effects. ACS Med Chem Lett. 2023 Nov 27;14(12):1839-1847.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported