NF-κB-IN-4

• UNSPSC Description:

  NF-κB-IN-4 (compound 17) is a potent and BBB-penetrated NF-κB pathway inhibitor with blood brain barrier (BBB) permeability. NF-κB-IN-4 exhibits potential anti-neuroinflammatory activity with low toxicity. NF-κB-IN-4 can block the activation and phosphorylation of IκBα, reduce expression of NLRP3, and thus inhibit NF-κB activation. NF-κB-IN-4 can be used for neuroinflammation related diseases research[1].

• Target Antigen:

  Apoptosis; NF-κB

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/nf-κb-in-4.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic;warming;heat to 150°C)

• Smiles:

  COC1=CC(C2=C3CCC4=C(C3=NC(N)=N2)C=C(C=C4)F)=CN=C1

• Molecular Weight:

  322.34

• References & Citations:

  [1]Zhang XF, et al. Anti-neuroinflammatory effects of novel 5,6-dihydrobenzo[h]quinazolin-2-amine derivatives in lipopolysaccharide-stimulated BV2 microglial cells. Eur J Med Chem. 2022;235:114322.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported