NF-κB-IN-4

NF-κB-IN-4

• UNSPSC Description: NF-κB-IN-4 (compound 17) is a potent and BBB-penetrated NF-κB pathway inhibitor with blood brain barrier (BBB) permeability. NF-κB-IN-4 exhibits potential anti-neuroinflammatory activity with low toxicity. NF-κB-IN-4 can block the activation and phosphorylation of IκBα, reduce expression of NLRP3, and thus inhibit NF-κB activation. NF-κB-IN-4 can be used for neuroinflammation related diseases research[1].
• Target Antigen: Apoptosis; NF-κB
• Type: Reference compound
• Related Pathways: Apoptosis;NF-κB
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/nf-κb-in-4.html
• Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 150°C)
• Smiles: COC1=CC(C2=C3CCC4=C(C3=NC(N)=N2)C=C(C=C4)F)=CN=C1
• Molecular Weight: 322.34
• References & Citations: [1]Zhang XF, et al. Anti-neuroinflammatory effects of novel 5,6-dihydrobenzo[h]quinazolin-2-amine derivatives in lipopolysaccharide-stimulated BV2 microglial cells. Eur J Med Chem. 2022;235:114322.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported