NF-κB-IN-4

CAT: 0804-HY-144765-01Size: 5 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-144765-01Size:5 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

NF-κB-IN-4 (compound 17) is a potent and BBB-penetrated NF-κB pathway inhibitor with blood brain barrier (BBB) permeability. NF-κB-IN-4 exhibits potential anti-neuroinflammatory activity with low toxicity. NF-κB-IN-4 can block the activation and phosphorylation of IκBα, reduce expression of NLRP3, and thus inhibit NF-κB activation. NF-κB-IN-4 can be used for neuroinflammation related diseases research[1].

UNSPSC

12352005

Target

Apoptosis; NF-κB

Type

Reference compound

Related Pathways

Apoptosis; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nf-κb-in-4.html

Concentration

10mM

Purity

98.51

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 150°C)

Smiles

COC1=CC(C2=C3CCC4=C(C3=NC(N)=N2)C=C(C=C4)F)=CN=C1

Molecular Formula

C18H15FN4O

Molecular Weight

322.34

References & Citations

[1]Zhang XF, et al. Anti-neuroinflammatory effects of novel 5,6-dihydrobenzo[h]quinazolin-2-amine derivatives in lipopolysaccharide-stimulated BV2 microglial cells. Eur J Med Chem. 2022;235:114322.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Related Products

Catalog	Name
HY-175833	NF-κB-IN-20
HY-158156	NF-κB-IN-16
HY-144744	NF-κB-IN-3
HY-149838	NF-κB-IN-9
HY-149248	NF-κB-IN-8
HY-149580	NF-κB-IN-12
HY-162004	NF-κB-IN-14
HY-126026	NF-κB-IN-17
HY-138537-01	NF-κB-IN-1
HY-147770	NF-κB-IN-6

Alternative Products

Catalog	Name
T60868	NF-κB-IN-4
60614	NF-κB Reporter Kit (NF-κB Signaling Pathway)
BA8604-1	NF-κB-IN-1
T208821-01	NF-κB-IN-14
T89612-01	NF-κB-IN-17
T62060-01	NF-κB-IN-5
T78750-01	NF-κB-IN-10
sc-3061	NFκB control
AI70006A-01	NF-қB-p65
sc-3060A	NFκB Inhibitor

NF-κB-IN-4

Related Products

Alternative Products

Popular Products