NF-κB-IN-1

CAT: 0804-HY-138537-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-138537-01Size:1 mg

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Description

NF-κB-IN-1, a 4-arylidene crucumin analogue, is a potent NF-κB signaling pathway inhibitor. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κB-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells[1].

CAS Number

1227098-15-8

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IKK

Type

Reference compound

Related Pathways

NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nf-κb-in-1.html

Concentration

10mM

Purity

98.37

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(/C=C/C(C=C1)=CC(OC)=C1OC)/C(C(/C=C/C(C=C2)=CC(OC)=C2OC)=O)=C/C(C=C3)=CC(OC)=C3O

Molecular Formula

C31H30O8

Molecular Weight

530.57

Precautions

H302, H315, H319, H335

References & Citations

[1]Qiu X, et, al. Synthesis and identification of new 4-arylidene curcumin analogues as potential anticancer agents targeting nuclear factor-κB signaling pathway. J Med Chem. 2010 Dec 9;53 (23) :8260-73.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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Catalog	Name
BA8604-1	NF-κB-IN-1
BUP07719-01	NF-?B-IN-1
T203058-01	TLR4/NF-κB-IN-1
T210896-01	NF-κB degrader 1
GTR19185557-01	NF-κB/PON1-IN-1
T63119-01	NF-κB/MAPK-IN-1
BUP05080-01	NF-?B/MAPK-IN-1
GTR19263792-01	STAT3/NF-κB-IN-1
T207236-01	NF-κB/HIF-1α-IN-1
GTR19186540-01	Akt/NF-κB/JNK-IN-1

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