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EGFR-IN-133

CAT: 0804-HY-169309Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169309Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGFR-IN-133 (Compound 24) is an inhibitor for EGFR, that inhibits the EGFR wildtype, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S mutans with IC50 of 0.1, 0.044, 0.036, 0.04, and 0.054 nM. EGFR-IN-133 exhibits good pharmacokinetics characteristics with high oral exposure[1].
CAS Number
2809982-26-9
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-133.html
Smiles
FC1=C2N3/C(NC2=CC(N[C@@H]4CCOC4)=C1)=N/C(C5=CC(F)=NC(C6=C(N(N=C6)C)OCCC[C@H](C3)C)=C5)=O
Molecular Formula
C27H29F2N7O3
Molecular Weight
537.56
References & Citations
[1]Liu F, et al., Macrocyclic compound containing benzoheterocycle and acting as egfr kinase inhibitor, and pharmaceutical composition and use thereof. WO2022166741
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1

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