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XY028-133

CAT: 0804-HY-129180-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-129180-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XY028-133 (example 14) is a PROTAC-based CDK4/6 degrader with anti-tumor activity, which consists of ligands for von Hippel-Lindau and CDK[1].
CAS Number
2229974-73-4
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
CDK; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xy028-133.html
Purity
98.62
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(CCCCCC(N4CCN(C5=CC=C(NC6=NC=C(C(C)=C(C(C)=O)C(N7C8CCCC8)=O)C7=N6)N=C5)CC4)=O)=O)=O)C[C@H](O)C3
Molecular Formula
C53H67N11O7S
Molecular Weight
1002.23
Precautions
H302, H312, H332
References & Citations
[1]JIN, Jian, et al. COMPOSITIONS AND METHODS FOR TREATING CDK4/6-MEDIATED CANCER. Patent. US2017/065027.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4; CDK6

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Alternative Products

CatalogName
BA3796-10XY028-133
A23959-10XY028-133 10mg
A23959-5XY028-133 5mg
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A23913-50XY028-140 (MS140) 50mg
A23913-10XY028-140 (MS140) 10mg
A23913-100XY028-140 (MS140) 100mg
A23913-5XY028-140 (MS140) 5mg

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