JE-133

CAT: 0804-HY-163151Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-163151Size:1 Each
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Description
JE-133 is an optically active isochromane-2H-chromene conjugate. JE-133 exhibits antioxidant and anti-inflammatory activities. JE-133 is a neuroprotective agent that effectively inhibits neuronal oxidative damage associated with PI3K/Akt and MAPK signaling pathways. JE-133 can also inhibit lipopolysaccharide (LPS) (HY-D1056) -induced neuroinflammation by regulating JAK/STAT and Nrf2 signaling pathways[1][2].
CAS Number
[2579171-69-8]
UNSPSC
12352005
Target
Akt; p38 MAPK; PI3K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/je-133.html
Solubility
10 mM in DMSO
Smiles
CCOC([C@@H]1C([C@H]2C3=CC(O)=C(O)C=C3C[C@H](O2)C)=CC4=CC(OC)=CC=C4O1)=O
Molecular Formula
C23H24O7
Molecular Weight
412.43
References & Citations
[1]Tao L, et al. JE-133 Suppresses LPS-Induced Neuroinflammation Associated with the Regulation of JAK/STAT and Nrf2 Signaling Pathways[J]. ACS Chemical Neuroscience, 2024.|[2]Tao L, et al. An optically active isochroman-2 H-chromene conjugate potently suppresses neuronal oxidative injuries associated with the PI3K/Akt and MAPK signaling pathways[J]. Acta Pharmacologica Sinica, 2021, 42 (1) : 36-44.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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