ML-133

• Description :

  ML133 is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H318-H335

• Target :

  Potassium Channel

• Related Pathways :

  Membrane Transporter/Ion Channel

• Field of Research :

  Others

• Solubility :

  10 mM in DMSO

• Smiles :

  COC1=CC=C(CNCC2=C3C=CC=CC3=CC=C2)C=C1

• Molecular Formula :

  C19H19NO

• Molecular Weight :

  277.36

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Wang HR, et al. Selective inhibition of the K (ir) 2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. ACS Chem Biol. 2011 Aug 19;6 (8) :845-56.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound2

• Clinical Information :

  No Development Reported

• CAS Number :

  [185669-79-8]