KS-133 (TFA)

• Description:

  KS-133 TFA is a selective and potent antagonist of vasoactive intestinal peptide receptor 2 (VIPR2), with the IC50 values of 24.8 nM and 500 nM in Ca influx assay and cAMP assay. KS-133 TFA plays an important role in schizophrenia research[1].

• UNSPSC:

  12352209

• Target:

  PACAP Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ks-133-tfa.html

• Purity:

  99.27

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (N (CCC1) [C@]1 ([H]) C (N[C@H] (C (N[C@H] (C (N (CCC2) [C@]2 ([H]) C3=O) =O) CC (C) C) =O) CC (C=C4) =CC=C4O) =O) [C@@] (CCC5) ([H]) N5C ([C@H] (CSSC[C@@] (NC ([C@@H] (NC ([C@@H] (NC6=O) CC (C=C7) =CC=C7O) =O) CC (C) C) =O) ([H]) C (N[C@@H] (CC (NCCCC[C@]6 ([H]) N3) =O) C (N[C@@H] (CC (C) C) C (N[C@H] (C (N) =O) [C@@H] (C) CC) =O) =O) =O) NC (C) =O) =O.OC (C (F) (F) F) =O

• Molecular Formula:

  C77H112F3N15O19S2

• Molecular Weight:

  1672.93

• References & Citations:

  [1]Kotaro Sakamoto, et al. Generation of KS-133 as a Novel Bicyclic Peptide with a Potent and Selective VIPR2 Antagonist Activity that Counteracts Cognitive Decline in a Mouse Model of Psychiatric Disorders. Front Pharmacol. 2021 Nov 4:12:751587.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported