KS-133

• Description:

  KS-133 is a selective and potent antagonist of vasoactive intestinal peptide receptor 2 (VIPR2), with the IC50 values of 24.8 nM and 500 nM in Ca influx assay and cAMP assay. KS-133 plays an important role in schizophrenia research[1].

• UNSPSC:

  12352209

• Target:

  PACAP Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ks-133.html

• Purity:

  98.75

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(N(CCC1)[C@]1([H])C(N[C@H](C(N[C@H](C(N(CCC2)[C@]2([H])C3=O)=O)CC(C)C)=O)CC(C=C4)=CC=C4O)=O)[C@@](CCC5)([H])N5C([C@H](CSSC[C@@](NC([C@@H](NC([C@@H](NC6=O)CC(C=C7)=CC=C7O)=O)CC(C)C)=O)([H])C(N[C@@H](CC(NCCCC[C@]6([H])N3)=O)C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)[C@@H](C)CC)=O)=O)=O)NC(C)=O)=O

• Molecular Formula:

  C75H111N15O17S2

• Molecular Weight:

  1558.90

• References & Citations:

  [1]Kotaro Sakamoto, et al. Generation of KS-133 as a Novel Bicyclic Peptide with a Potent and Selective VIPR2 Antagonist Activity that Counteracts Cognitive Decline in a Mouse Model of Psychiatric Disorders. Front Pharmacol. 2021 Nov 4:12:751587.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  [2724212-01-3]