NFAT-133

• Description:

  NFAT-133 is an aromatic polyketide with immunosuppressive and antidiabetic activity. NFAT-133 activates the AMPK pathway, promoting glucose uptake in L6 muscle fibers, thereby resisting diabetes. NFAT-133 inhibits the transcriptional activity of activated T-cell nuclear factor (NFAT), thereby suppressing the expression of IL-2 and the proliferation of T cells, demonstrating an immunosuppressive effect. NFAT-133 does not exhibit antibacterial activity or cytotoxicity, but it can weaken the production of NO in RAW264.7 cells induced by Lipopolysaccharide (LPS) (HY-D1056) [1][2][3][4].

• UNSPSC:

  12352005

• Target:

  AMPK; Endogenous Metabolite; Interleukin Related; Nuclear Factor of activated T Cells (NFAT)

• Related Pathways:

  Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

• Field of Research:

  Metabolic Disease; Inflammation/Immunology

• Smiles:

  CC ([C@@H] (C) [C@H] (O) [C@H] (C1=C (C=C (C=C1) C) /C=C/CO) C) =O

• Molecular Formula:

  C17H24O3

• Molecular Weight:

  276.37

• References & Citations:

  [1]Yang Y, et al. Absolute configuration of NFAT-133, an aromatic polyketide with immunosuppressive and antidiabetic activity from actinomycetes. J Antibiot (Tokyo) . 2016 Jan;69 (1) :69-71. |[2]Thakkar CS, et al. NFAT-133 increases glucose uptake in L6 myotubes by activating AMPK pathway. Eur J Pharmacol. 2015 Dec 15;769:117-26. |[3]Zhou W, et al. Identification and Biological Activity of NFAT-133 Congeners from Streptomyces pactum. J Nat Prod. 2021 Sep 24;84 (9) :2411-2419. |[4]Kulkarni-Almeida AA, et al. Fermentation, Isolation, Structure, and antidiabetic activity of NFAT-133 produced by Streptomyces strain PM0324667. AMB Express. 2011 Nov 21;1 (1) :42.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  AMPK; IL-2

• CAS Number:

  165133-85-7