NFAT-133

CAT: 0804-HY-N16431Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-N16431Size:1 Each
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Description
NFAT-133 is an aromatic polyketide with immunosuppressive and antidiabetic activity. NFAT-133 activates the AMPK pathway, promoting glucose uptake in L6 muscle fibers, thereby resisting diabetes. NFAT-133 inhibits the transcriptional activity of activated T-cell nuclear factor (NFAT), thereby suppressing the expression of IL-2 and the proliferation of T cells, demonstrating an immunosuppressive effect. NFAT-133 does not exhibit antibacterial activity or cytotoxicity, but it can weaken the production of NO in RAW264.7 cells induced by Lipopolysaccharide (LPS) (HY-D1056) [1][2][3][4].
CAS Number
[165133-85-7]
UNSPSC
12352005
Target
AMPK; Endogenous Metabolite; Interleukin Related; Nuclear Factor of activated T Cells (NFAT)
Related Pathways
Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
CC([C@@H](C)[C@H](O)[C@H](C1=C(C=C(C=C1)C)/C=C/CO)C)=O
Molecular Formula
C17H24O3
Molecular Weight
276.37
References & Citations
[1]Yang Y, et al. Absolute configuration of NFAT-133, an aromatic polyketide with immunosuppressive and antidiabetic activity from actinomycetes. J Antibiot (Tokyo) . 2016 Jan;69 (1) :69-71. |[2]Thakkar CS, et al. NFAT-133 increases glucose uptake in L6 myotubes by activating AMPK pathway. Eur J Pharmacol. 2015 Dec 15;769:117-26. |[3]Zhou W, et al. Identification and Biological Activity of NFAT-133 Congeners from Streptomyces pactum. J Nat Prod. 2021 Sep 24;84 (9) :2411-2419. |[4]Kulkarni-Almeida AA, et al. Fermentation, Isolation, Structure, and antidiabetic activity of NFAT-133 produced by Streptomyces strain PM0324667. AMB Express. 2011 Nov 21;1 (1) :42.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AMPK; IL-2

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