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MHP 133

CAT: 0804-HY-101653Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101653Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MHP 133 is a agent with multiple CNS targets, and inhibits acetylcholinesterase (AChE) with Ki of 69 μM; also active against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors.
CAS Number
147340-43-0
UNSPSC
12352005
Target
5-HT Receptor; Cholinesterase (ChE) ; mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/MHP_133.html
Solubility
10 mM in DMSO
Smiles
O=C(N/N=C/C1=C(OC(N(C)C)=O)C=CC=[N+]1C)NC2=CC=CC=C2.[Cl-]
Molecular Formula
C17H20ClN5O3
Molecular Weight
377.83
References & Citations
[1]Buccafusco JJ, et al. MHP-133, a drug with multiple CNS targets: potential for neuroprotection and enhanced cognition. Neurochem Res. 2007 Jul;32 (7) :1224-37. Epub 2007 Apr 3.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; Apolipoprotein D; mAChR1; mAChR2

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