MHP 133

• Description:

  MHP 133 is a agent with multiple CNS targets, and inhibits acetylcholinesterase (AChE) with Ki of 69 μM; also active against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors.

• UNSPSC:

  12352005

• Target:

  5-HT Receptor; Cholinesterase (ChE) ; mAChR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/MHP_133.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (N/N=C/C1=C (OC (N (C) C) =O) C=CC=[N+]1C) NC2=CC=CC=C2.[Cl-]

• Molecular Formula:

  C17H20ClN5O3

• Molecular Weight:

  377.83

• References & Citations:

  [1]Buccafusco JJ, et al. MHP-133, a drug with multiple CNS targets: potential for neuroprotection and enhanced cognition. Neurochem Res. 2007 Jul;32 (7) :1224-37. Epub 2007 Apr 3.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AChE; Apolipoprotein D; mAChR1; mAChR2

• CAS Number:

  147340-43-0