MHP 133

• Description :

  MHP 133 is a agent with multiple CNS targets, and inhibits acetylcholinesterase (AChE) with Ki of 69 μM; also active against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors.

• UNSPSC :

  12352005

• Target :

  5-HT Receptor; Cholinesterase (ChE) ; mAChR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/MHP_133.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N/N=C/C1=C(OC(N(C)C)=O)C=CC=[N+]1C)NC2=CC=CC=C2.[Cl-]

• Molecular Formula :

  C17H20ClN5O3

• Molecular Weight :

  377.83

• References & Citations :

  [1]Buccafusco JJ, et al. MHP-133, a drug with multiple CNS targets: potential for neuroprotection and enhanced cognition. Neurochem Res. 2007 Jul;32 (7) :1224-37. Epub 2007 Apr 3.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  AChE; Apolipoprotein D; mAChR1; mAChR2

• CAS Number :

  [147340-43-0]