COG 133

CAT: 0804-HY-P1050-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P1050-01Size:1 mg
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Description
COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also a nAChR antagonist with an IC50 of 445 nM[1][2].
CAS Number
[514200-66-9]
UNSPSC
12352209
Target
Apolipoprotein; nAChR
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cog-133.html
Purity
98.72
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[C@H](CC1=CN=CN1)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N)=O)=O)CC(C)C)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCCCN)=O)CCCNC(=N)N)=O)CC(C)C)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC(C)=O)=O)CCCNC(=N)N)=O)C(C)C)=O)CCCNC(=N)N)=O)CC(C)C)=O)C)=O)CO)=O
Molecular Formula
C97H181N37O19
Molecular Weight
2169.71
References & Citations
[1]Orleâncio Gomes R Azevedo, et al. Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis. BMC Gastroenterol. 2012 Jul 13;12:35.|[2]Elaine A Gay, et al. Apolipoprotein E-derived peptides block alpha7 neuronal nicotinic acetylcholine receptors expressed in xenopus oocytes. J Pharmacol Exp Ther. 2006 Feb;316 (2) :835-42.|[3]Huachun Cui, et al. Monocyte-derived alveolar macrophage apolipoprotein E participates in pulmonary fibrosis resolution. JCI Insight. 2020 Mar 12;5 (5) :e134539.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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