EGFR-IN-133

CAT: 0931-MF-0110983-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0110983-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2809982-26-9
Target
EGFR|||Antifungal
Related Pathways
JAK/STAT signaling|||Angiogenesis|||Microbiology/Virology|||Tyrosine Kinase/Adaptors
Bioactivity
EGFR-IN-133 (Compound 24) serves as an inhibitor targeting various mutations of the EGFR, including the wild type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with respective IC50 values of 0.1, 0.044, 0.036, 0.04, and 0.054 nM. The compound exhibits favorable pharmacokinetic properties and high oral bioavailability.
Smiles
FC1=C2N3C(NC2=CC(N[C@@H]4CCOC4)=C1)=NC(=O)C=5C=C(C6=C(OCCC[C@@H](C)C3)N(C)N=C6)N=C(F)C5
Molecular Formula
C27H29F2N7O3
Molecular Weight
537.56
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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