EGFR-IN-133

CAT: 0931-T201790-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T201790-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2809982-26-9

Target

EGFR, Antifungal

Related Pathways

JAK/STAT signaling, Angiogenesis, Microbiology/Virology, Tyrosine Kinase/Adaptors

Bioactivity

EGFR-IN-133 (Compound 24) serves as an inhibitor targeting various mutations of the EGFR, including the wild type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with respective IC50 values of 0.1, 0.044, 0.036, 0.04, and 0.054 nM. The compound exhibits favorable pharmacokinetic properties and high oral bioavailability.

Smiles

FC1=C2N3C(NC2=CC(N[C@@H]4CCOC4)=C1)=NC(=O)C=5C=C(C6=C(OCCC[C@@H](C)C3)N(C)N=C6)N=C(F)C5

Molecular Formula

C27H29F2N7O3

Molecular Weight

537.56

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
HY-169309	EGFR-IN-133
GTR19143831-01	Human EGFR (25-133) Protein, hFc Tag
C4664-10	RSC-133
B7941-5	JWH 133
HY-106026	YM 133
HY-P6292	KS-133
HY-P1050-01	COG 133
464867-01	RSC 133
7952/10U	CELT-133
ARC0212	FTC-133

EGFR-IN-133

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