Antitumor agent-177

CAT: 0804-HY-161841Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-161841Size:1 Each
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Description
Antitumor agent-177 (compound 57), a non-steroidal NSC12 derivative, shows potent FGF2 binding affinity with a Kd of 24 μM by SPR. Antitumor agent-177 significantly inhibits the formation of HSPG/FGF2/FGFR1 ternary complexes. Antitumor agent-177 inhibits FGFR activation and exerts a potent anti-tumor activity on multiple myeloma (MM) cell lines in vitro and in vivo[1].
CAS Number
[9007-83-4]
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-177.html
Smiles
OC(C1=CC=C(C2=CC=C3C=C(O)C=CC3=C2)C(COC4=CC=C(F)C=C4)=C1)CC(O)(C(F)(F)F)C(F)(F)F
Molecular Formula
C28H21F7O4
Molecular Weight
554.45
References & Citations
[1]Sara Taranto, et al. Discovery of novel FGF trap small molecules endowed with anti-myeloma activity. Pharmacol Res. 2024 Jul 3:206:107291.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FGFR

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