Antitumor agent-19

CAT: 0804-HY-128776Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-128776Size:1 mg
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Description
Antitumor agent-19 is an antitumor agent that targets tumor-associated macrophages (TAMs) and can be used as a potent TAMs modulator. Antitumor agent-19 can increase TNF-alpha levels in tumor cells with EC50 values of 17.18 μM and 18.87 μM in RAW 264.7 cells and BMDM cells, respectively[1].
CAS Number
[2379727-90-7]
UNSPSC
12352005
Target
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-19.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1CCC(NC2=C3C(C4=CN(C)N=C4)=CC=C2)=C3C1)NC5=CC=C(Cl)C(C(F)(F)F)=C5
Molecular Formula
C24H21ClF3N5O
Molecular Weight
487.90
References & Citations
[1]Pei H, et al. iscovery of potent ureido tetrahydrocarbazole derivatives for cancer treatments through targeting tumor-associated macrophages. Eur J Med Chem. 2019 Sep 28;183:111741.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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