Antitumor agent-19

• Description :

  Antitumor agent-19 is an antitumor agent that targets tumor-associated macrophages (TAMs) and can be used as a potent TAMs modulator. Antitumor agent-19 can increase TNF-alpha levels in tumor cells with EC50 values of 17.18 μM and 18.87 μM in RAW 264.7 cells and BMDM cells, respectively[1].

• CAS Number :

  [2379727-90-7]

• UNSPSC :

  12352005

• Target :

  TNF Receptor

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/antitumor-agent-19.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NC1CCC(NC2=C3C(C4=CN(C)N=C4)=CC=C2)=C3C1)NC5=CC=C(Cl)C(C(F)(F)F)=C5

• Molecular Formula :

  C24H21ClF3N5O

• Molecular Weight :

  487.90

• References & Citations :

  [1]Pei H, et al. iscovery of potent ureido tetrahydrocarbazole derivatives for cancer treatments through targeting tumor-associated macrophages. Eur J Med Chem. 2019 Sep 28;183:111741.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported