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Antitumor agent-130

CAT: 0804-HY-162128Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162128Size:1 Each
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Description
Antitumor agent-130 (Compound 7b) is a p300 histone acetyltransferases (HAT) inhibitor with an IC50 of 1.51 μM. Antitumor agent-130 combinates with doxorubicin can significantly inhibit tumor growth and invasion in vitro and in vivo[1].
CAS Number
9007-83-4
UNSPSC
12352005
Target
Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-130.html
Solubility
10 mM in DMSO
Smiles
COC1=C(OC)C=C(C=C(C2=CC(OCO3)=C3C=C2OCC4)[N+]4=C5)C5=C1.[Cl-]
Molecular Formula
C20H18ClNO5
Molecular Weight
387.81
References & Citations
[1]Lai R, et al. Novel berberine derivatives as p300 histone acetyltransferase inhibitors in combination treatment for breast cancer. Eur J Med Chem. 2024 Jan 6;266:116116.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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