Antitumor agent-130

• UNSPSC Description:

  Antitumor agent-130 (Compound 7b) is a p300 histone acetyltransferases (HAT) inhibitor with an IC50 of 1.51 μM. Antitumor agent-130 combinates with doxorubicin (HY-15142A) can significantly inhibit tumor growth and invasion in vitro and in vivo[1].

• Target Antigen:

  Histone Acetyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/antitumor-agent-130.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=C(OC)C=C(C=C(C2=CC(OCO3)=C3C=C2OCC4)[N+]4=C5)C5=C1.[Cl-]

• Molecular Weight:

  387.81

• References & Citations:

  [1]Lai R, et al. Novel berberine derivatives as p300 histone acetyltransferase inhibitors in combination treatment for breast cancer. Eur J Med Chem. 2024 Jan 6;266:116116.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  9007-83-4