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Antitumor agent-159

CAT: 0804-HY-116447-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-116447-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Antitumor agent-159 (Compound 13b) targets the mitochondria and downregulates cardiolipin levels. Antitumor agent-159 inhibits the proliferation of cancer cell MDA-MB-231, arrests the cell cycle at sub-G1 phase, and induces apoptosis in MDA-MB-231. Antitumor agent-159 exhibits antitumor efficacy in MDA-MB-231 xenograft mouse models[1].
CAS Number
1611446-66-2
Product Name Alternative
Pentacarboxybenzene
UNSPSC
12352005
Target
Apoptosis; Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-159.html
Purity
99.0
Smiles
ClC1=CC=C(C=C1C(F)(F)F)NC(NCCCCCCCCCCCCCCCC(O)=O)=O
Molecular Formula
C24H36ClF3N2O3
Molecular Weight
493.00
References & Citations
[1]Rawling T, et al., A Novel Arylurea Fatty Acid That Targets the Mitochondrion and Depletes Cardiolipin To Promote Killing of Breast Cancer Cells. J Med Chem. 2017 Oct 26;60 (20) :8661-8666.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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