Products for Research Use Only
RegisterLogin

Antitumor agent-163

CAT: 0804-HY-163691Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-163691Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Antitumor agent-163 (Compound 3) is a photosensitizer used in Molecular-Targeted Photodynamic Therapy (MT-PDT) targeting carbonic anhydrase IX (CAIX) . Antitumor agent-163 inactivates CAIX protein via singlet oxygen under 540 nm wavelength light, without affecting internal standard proteins such as α-tubulin, β-actin, and proliferating cell nuclear antigen (PCNA) . Antitumor agent-163 induces cell membrane damage, inhibits cell viability (IC50 is 0.2 and 0.05 μM for A549 and U87MG) . Antitumor agent-163 exhibits antitumor efficacy in mouse model[1].
CAS Number
9007-83-4
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-163.html
Smiles
O=S(C1=CC=C(C(NCCCCCCNC(CCC2=[N+](C(C=C2I)=C3)[B-](F)(F)N4C3=C(C)C(I)=C4C)=O)=O)C=C1)(N)=O
Molecular Formula
C27H32BF2I2N5O4S
Molecular Weight
825.26
References & Citations
[1]Miura K, et al., Development of carbonic anhydrase IX-targeting molecular-targeted photodynamic therapy. Bioorg Med Chem Lett. 2024 May 27;109:129821.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-163768-01Antitumor agent-172
HY-162128Antitumor agent-130
HY-161425Antitumor agent-149
HY-155034Antitumor agent-102
HY-151292Antitumor agent-74
HY-145289Antitumor agent-37
HY-146409Antitumor agent-59
HY-149717Antitumor agent-122
HY-115948Antitumor agent-46
HY-152537Antitumor agent-84

Alternative Products

CatalogName
GTR19262514-01Antitumor agent-163
T10342-01Antitumor agent-2
T211211-01Antitumor agent-203
T209984-01Antitumor agent-156
T209806-01Antitumor agent-151
T209096-01Antitumor agent-131
T206452-01Antitumor agent-200
T205444-01Antitumor agent-198
T200846-01Antitumor agent-188
T89076-01Antitumor agent-175

Popular Products