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Antitumor agent-149

CAT: 0804-HY-161425Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161425Size:1 Each
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Description
Antitumor agent-149 (Compound 3) is an analogue of Echinomycin. Antitumor agent-149 inhibits HIF-1α-mediated transcription. Antitumor agent-149 induces cancer cell apoptosis. Antitumor agent-149 inhibits tumor growth in SW620 xenograft mice model[1].
CAS Number
2368983-54-2
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-149.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](C(N[C@H](C(N([C@@H](CSC1)C(N([C@H]2C(C)C)C)=O)C)=O)C)=O)COC([C@H](C(C)C)N(C([C@H]1N(C([C@H](C)NC([C@H](NC(C3=NC(C=CC=C4)=C4C=C3O)=O)COC2=O)=O)=O)C)=O)C)=O)C5=NC(C=CC=C6)=C6C=C5O
Molecular Formula
C52H64N10O14S
Molecular Weight
1085.19
References & Citations
[1]Kojima K, et al. Synthesis and biological evaluation of echinomycin analogues as potential colon cancer agent. Sci Rep. 2024 Apr 1;14 (1) :7628.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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