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Antitumor agent-102

CAT: 0804-HY-155034Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155034Size:1 Each
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Description
Antitumor agent-102 (compound 10) is a conjugate of Topoisomerase I inhibitor SN38 and glucose transporter inhibitor, targeting to colorectal cancer. Antitumor agent-102 induces higher concentrations of free SN38 in tumor tissues than Irinotecan.
CAS Number
9007-83-4
UNSPSC
12352005
Target
GLUT; Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-102.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCCCC(N[C@H](C(N[C@H](C(NC2=CC=C(C=C2)COC3=CC=C(C4=C3)N=C5C(N6CC5=C4CC)=CC([C@@](CC)7O)=C(C6=O)COC7=O)=O)CCCNC(N)=O)=O)C(C)C)=O)C(SCCOCCOCCOC8=CC(O)=C(C(O)=C8)C(CCC9=CC=C(C=C9)O)=O)CC1=O
Molecular Formula
C70H82N8O18S
Molecular Weight
1355.51
References & Citations
[1]Chiu PF, et al. Design, Synthesis, and Evaluation of Glucose Transporter Inhibitor-SN38 Conjugates for Targeting Colorectal Cancer. J Med Chem. 2023 Jul 6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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