ERα degrader 7

• UNSPSC Description:

  ERα degrader 7 (compound B1) is a potent ERα degrader with an IC50 of 14.6 nM and a DC50 of 9.7 nM, respectively. ERα degrader 7 shows excellent antitumor activity, indicating its potential to evolve as a promising selective estrogen-receptor degrader (SERD) for breast cancer research[1].

• Target Antigen:

  Estrogen Receptor/ERR

• Type:

  Reference compound

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/erα-degrader-7.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC(C1=CC=C(C2=CC(F)=C([C@@H]3C(NC4=CC=CC=C45)=C5C[C@@H](C)N3CC(F)(F)CO)C(F)=C2)C=C1)=O

• Molecular Weight:

  512.50

• References & Citations:

  [1]Haohao Zhu, et al. Hot-Spot Residue-Based Virtual Screening of Novel Selective Estrogen-Receptor Degraders for Breast Cancer Treatment. Journal of Chemical Information and Modeling. 2023, Article ASAP.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported