Products for Research Use Only
RegisterLogin

ERα degrader 7

CAT: 0804-HY-155492Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-155492Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ERα degrader 7 (compound B1) is a potent ERα degrader with an IC50 of 14.6 nM and a DC50 of 9.7 nM, respectively. ERα degrader 7 shows excellent antitumor activity, indicating its potential to evolve as a promising selective estrogen-receptor degrader (SERD) for breast cancer research[1].
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/erα-degrader-7.html
Solubility
10 mM in DMSO
Smiles
OC(C1=CC=C(C2=CC(F)=C([C@@H]3C(NC4=CC=CC=C45)=C5C[C@@H](C)N3CC(F)(F)CO)C(F)=C2)C=C1)=O
Molecular Formula
C28H24F4N2O3
Molecular Weight
512.50
References & Citations
[1]Haohao Zhu, et al. Hot-Spot Residue-Based Virtual Screening of Novel Selective Estrogen-Receptor Degraders for Breast Cancer Treatment. Journal of Chemical Information and Modeling. 2023, Article ASAP.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-142925ER degrader 1
HY-176955ER degrader 12
HY-170806ERα degrader 12
HY-142927ER degrader 3
HY-144306ERα degrader 4
HY-155196ER degrader 6
HY-168101ERα degrader 11
HY-142926ER degrader 2
HY-176956ER degrader 13
HY-149970ER degrader 5

Alternative Products

CatalogName
TBI5001-5MGSTING Degrader 1, STING degrader
T74545-01STAT3 degrader-1
T211896-01GSPT1 degrader-7
T211514-01Lck degrader-1
T210553-01ER degrader 11
T209932-01CDK4 degrader 1
T209911-01BRD4 degrader-2
T209877-01AR Degrader-1
T209376-01Tubulin degrader 1
T207627-01CDK9 degrader-1

Popular Products