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ALK5-IN-25

CAT: 0804-HY-151270Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-151270Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ALK5-IN-25 (compound EX-02) is a potent ALK-5 inhibitor with an IC50 ≤10 nM.ALK5-IN-25 also inhibits ALK-2 (selectivity ALK2/ALK5≤10) . ALK5-IN-25 can be used for the research of cancer[1].
CAS Number
2785430-81-9
UNSPSC
12352005
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alk5-in-25.html
Solubility
10 mM in DMSO
Smiles
CC1=C(F)C=CC2=C(NC3=NC(NC4=CC=C(N5CCNCC5)C=C4)=NC=C3)C=NN=C12
Molecular Formula
C23H23FN8
Molecular Weight
430.48
References & Citations
[1]Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent WO2022126133A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALK2; ALK5

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