PARP1/BRD4-IN-2

PARP1/BRD4-IN-2

• CAS Number: 3037993-97-5
• UNSPSC Description: PARP1/BRD4-IN-2 is a potent and selective PARP1 and BRD4 inhibitor with IC50 values of 197 nM and 238 nM, respectively. PARP1/BRD4-IN-2 inhibits DNA damage repair, arrests G0/G1 transition and induces apoptosis. PARP1/BRD4-IN-2 has anti-tumor activity in MDA-MB-468 xenograft mouse model. PARP1/BRD4-IN-2 can be used for researching triple-negative breast cancer (TNBC)[1].
• Target Antigen: Apoptosis; Epigenetic Reader Domain; PARP
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/parp1-brd4-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1C2=CC=CC=C2C(CC3=CC=CC(C4=NC5=CC(OC)=CC(OC)=C5C(N4)=O)=C3)=NN1
• Molecular Weight: 440.45
• References & Citations: [1]Zhang J, et al. Discovery of 4-Hydroxyquinazoline Derivatives as Small Molecular BET/PARP1 Inhibitors That Induce Defective Homologous Recombination and Lead to Synthetic Lethality for Triple-Negative Breast Cancer Therapy. J Med Chem. 2022 May 12;65(9):6803-6825.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported