BRD4 degrader-2

BRD4 degrader-2

• CAS Number: 3036530-43-2
• UNSPSC Description: BRD4 degrader-2 (Compound JP-2-197) is a covalent monovalent molecular glue BRD4degrader that induces a ternary complex formation between BRD4 and RNF126. BRD4 degrader-2 targets RNF126 (E3 ligase) and degrades both the long and short isoforms of BRD4 in cells[1][2].
• Target Antigen: E1/E2/E3 Enzyme; Epigenetic Reader Domain; Molecular Glues
• Type: Reference compound
• Related Pathways: Epigenetics;Metabolic Enzyme/Protease;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/brd4-degrader-2.html
• Smiles: ClC1=CC=C(C2=N[C@@H](CC(N3CCN(C(/C=C/C(C4=CC=C(OC)C=C4)=O)=O)CC3)=O)C5=NN=C(C)N5C6=C2C(C)=C(C)S6)C=C1
• Molecular Weight: 657.18
• References & Citations: [1]Melissa Lim, et al. DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders. ACS Central Science. DOI: 10.1021/acscentsci.4c00286|[2]Toriki ES, et al. Rational Chemical Design of Molecular Glue Degraders. ACS Cent Sci. 2023 Apr 11;9(5):915-926.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported