BRD4 degrader-2

• Description:

  BRD4 degrader-2 (Compound JP-2-197) is a covalent monovalent molecular glue BRD4degrader that induces a ternary complex formation between BRD4 and RNF126. BRD4 degrader-2 targets RNF126 (E3 ligase) and degrades both the long and short isoforms of BRD4 in cells[1][2].

• UNSPSC:

  12352005

• Target:

  E1/E2/E3 Enzyme; Epigenetic Reader Domain; Molecular Glues

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; Metabolic Enzyme/Protease; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/brd4-degrader-2.html

• Smiles:

  ClC1=CC=C(C2=N[C@@H](CC(N3CCN(C(/C=C/C(C4=CC=C(OC)C=C4)=O)=O)CC3)=O)C5=NN=C(C)N5C6=C2C(C)=C(C)S6)C=C1

• Molecular Formula:

  C34H33ClN6O4S

• Molecular Weight:

  657.18

• References & Citations:

  [1]Melissa Lim, et al. DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders. ACS Central Science. DOI: 10.1021/acscentsci.4c00286|[2]Toriki ES, et al. Rational Chemical Design of Molecular Glue Degraders. ACS Cent Sci. 2023 Apr 11;9 (5) :915-926.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  BRD4

• CAS Number:

  [3036530-43-2]