Auxinole

• Description :

  Auxinole is a potent auxin antagonist of TIR1/AFB receptors, binding TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex and so inhibits auxin-responsive gene expression.

• CAS Number :

  [86445-22-9]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Others

• Type :

  Reference compound

• Related Pathways :

  Others

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/Auxinole.html

• Purity :

  99.77

• Solubility :

  DMSO : ≥ 125 mg/mL|Ethanol : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(O)C(CC(C1=CC=C(C)C=C1C)=O)C2=CNC3=C2C=CC=C3

• Molecular Formula :

  C20H19NO3

• Molecular Weight :

  321.37

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Hayashi K, et al. Rational design of an auxin antagonist of the SCF (TIR1) auxin receptor complex. ACS Chem Biol. 2012 Mar 16;7 (3) :590-8.|[2]Dindas J, et al. AUX1-mediated root hair auxin influx governs SCFTIR1/AFB-type Ca2+ signaling. Nat Commun. 2018 Mar 21;9 (1) :1174.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported