PLK1/BRD4-IN-2

PLK1/BRD4-IN-2

• CAS Number: 2251709-89-2
• UNSPSC Description: PLK1/BRD4-IN-2 (compound 15) is a BI-2536 (HY-50698) analog and dual inhibitor that targets both Polo-like kinase 1 (PLK1) and BRD4bromodomain (BRD4-BD1 IC50=28 nM, PLK1 IC50=40 nM)[1].
• Target Antigen: Epigenetic Reader Domain
• Type: Reference compound
• Related Pathways: Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/plk1-brd4-in-2.html
• Solubility: 10 mM in DMSO|DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: C[C@H]1N(C2CCCC2)C3=NC(NC4=C(C=C(C=C4)C(N5CCCCCC5)=O)OC)=NC=C3N(C1=O)C
• Molecular Weight: 492.61
• References & Citations: [1]Liu S, et al. Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors. J Med Chem. 2018 Sep 13;61(17):7785-7795.https://pubmed.ncbi.nlm.nih.gov/30125504/
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported