PARP1/BRD4-IN-3

• UNSPSC Description:

  PARP1/BRD4-IN-3 (compound HF4) is a potent BRD4 and PARP1 inhibitor with IC50 values of 1210, 2019 nM for BRD4, PARP1, respectively. PARP1/BRD4-IN-3 shows antiproliferative activities. PARP1/BRD4-IN-3 induces apoptosis and cell cycle arrest at G0/G1 phase. PARP1/BRD4-IN-3 causes DNA damage and reduces the protein expression of Rad51. PARP1/BRD4-IN-3 shows antitumor efficacy[1].

• Target Antigen:

  Apoptosis; DNA/RNA Synthesis; Epigenetic Reader Domain; PARP

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage;Epigenetics

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/parp1-brd4-in-3.html

• Smiles:

  O=S(C1=CC=C(F)C(C)=C1)(NC2=CC3=C(NC(C(CC)=C3)=O)C=C2)=O

• Molecular Weight:

  360.40

• References & Citations:

  [1]Feng B, et al. Combining Data-Driven and Structure-Based Approaches in Designing Dual PARP1-BRD4 Inhibitors for Breast Cancer Treatment. J Chem Inf Model. 2024 Oct 14;64(19):7725-7742.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported