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SA09-Cu

CAT: 0804-HY-150260Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-150260Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SA09-Cu is a noncompetitive and potent NDM-1 inhibitor with an IC50 of 9.6 nM. SA09-Cu can convert NDM-1 into an inactive state by oxidizing the Zn (II) -thiolate site of the enzyme and avoids to be reduced by intracellular thiols of bacteria. SA09-Cu exhibits excellent inhibition against a series of clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) in restoring the Meropenem (HY-13678) effect, and slows down the development of carbapenem resistance[1].
CAS Number
[155641-16-0]
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/sa09-cu.html
Solubility
10 mM in DMSO
Smiles
OCCN(C)C1=[S-][Cu+2]2(SC(N(C)CCO)=[S-]2)S1
Molecular Formula
C8H16CuN2O2S4
Molecular Weight
364.03
References & Citations
[1]Cheng Chen, et al. Dithiocarbamates combined with copper for revitalizing meropenem efficacy against NDM-1-producing Carbapenem-resistant Enterobacteriaceae. Bioorg Chem. 2022 Jan;118:105474.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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