CU-32

• UNSPSC Description:

  CU-32 is a potent cGAS inhibitor with an IC50 of 0.45 µM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells[1].

• Target Antigen:

  Cyclic GMP-AMP Synthase

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/cu-32.html

• Smiles:

  O=C(C1=NC(N)=NC(NC2=CC=C(I)C=C2)=N1)OC

• Molecular Weight:

  371.13

• References & Citations:

  [1]Padilla-Salinas R, et al. Discovery of Small-Molecule Cyclic GMP-AMP Synthase Inhibitors. J Org Chem. 2020 Feb 7;85(3):1579-1600.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2400954-16-5