CU-32

• Description :

  CU-32 is a potent cGAS inhibitor with an IC50 of 0.45 µM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells[1].

• UNSPSC :

  12352005

• Target :

  Cyclic GMP-AMP Synthase

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/cu-32.html

• Purity :

  98.8

• Solubility :

  DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(C1=NC(N)=NC(NC2=CC=C(I)C=C2)=N1)OC

• Molecular Formula :

  C11H10IN5O2

• Molecular Weight :

  371.13

• References & Citations :

  [1]Padilla-Salinas R, et al. Discovery of Small-Molecule Cyclic GMP-AMP Synthase Inhibitors. J Org Chem. 2020 Feb 7;85 (3) :1579-1600.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2400954-16-5]