CU-32

CAT: 0804-HY-132221-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-132221-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

CU-32 is a potent cGAS inhibitor with an IC50 of 0.45 µM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells[1].

CAS Number

2400954-16-5

UNSPSC

12352005

Target

Cyclic GMP-AMP Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cu-32.html

Purity

98.8

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=NC(N)=NC(NC2=CC=C(I)C=C2)=N1)OC

Molecular Formula

C11H10IN5O2

Molecular Weight

371.13

References & Citations

[1]Padilla-Salinas R, et al. Discovery of Small-Molecule Cyclic GMP-AMP Synthase Inhibitors. J Org Chem. 2020 Feb 7;85 (3) :1579-1600.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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CU-32

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