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CU-115

CAT: 0804-HY-131945-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131945-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CU-115 is a potent TLR8 antagonist (IC50=1.04 μM), and shows selective for TLR8 over TLR7 (IC50=>50 μM) . CU-115 decreases TNF-α and IL-1β production activated by R-848 in THP-1 cells[1].
CAS Number
2471982-20-2
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cu-115.html
Purity
99.63
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(OC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C=C1)C3=C(I)C=CC=C3F
Molecular Formula
C21H11F7INO2
Molecular Weight
569.21
References & Citations
[1]Rosaura Padilla-Salinas, et al. Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-Like Receptors 7 and 8. J Med Chem. 2019 Nov 27;62 (22) :10221-10244.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR7; TLR8

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