CU-CPT22

CAT: 0804-HY-108471-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-108471-01Size:5 mg
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Description
CU-CPT22 is a potent protein complex of toll-like receptor 1 and 2 (TLR1/2) inhibitor, and competes with the synthetic triacylated lipoprotein (Pam3CSK4) binding to TLR1/2 with a Ki of 0.41 µM. CU-CPT22 blocks Pam3CSK4-induced TLR1/2 activation with an IC50 of 0.58 µM[1].
CAS Number
[1416324-85-0]
UNSPSC
12352005
Hazard Statement
H334, H410
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CU_CPT_22.html
Purity
99.0
Solubility
DMSO : ≥ 125 mg/mL
Smiles
O=C(C(C=C1O)=CC2=CC(OC)=C(O)C(O)=C2C1=O)OCCCCCC
Molecular Formula
C19H22O7
Molecular Weight
362.37
Precautions
H334, H410
References & Citations
[1]Cheng K, et al. Discovery of small-molecule inhibitors of the TLR1/TLR2 complex. Angew Chem Int Ed Engl. 2012 Dec 3;51 (49) :12246-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR1; TLR2

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