CU-32

• Target:

  Others|||cGAS

• Related Pathways:

  Immunology/Inflammation|||Others

• Bioactivity:

  CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50= 0.45 ?M) .1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective for cGAS over toll-like receptors (TLRs) at 50 ?M. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-? in THP-1 cells when used at concentrations of 10, 30, and 100 ?M.

• Smiles:

  N(C=1N=C(C(OC)=O)N=C(N)N1)C2=CC=C(I)C=C2

• Molecular Formula:

  C11H10IN5O2

• Molecular Weight:

  371.13

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2400954-16-5