CU-32

CAT: 0931-T38328-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T38328-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2400954-16-5

Target

Others, cGAS

Related Pathways

Immunology/Inflammation, Others

Bioactivity

CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50= 0.45 μM) .1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective for cGAS over toll-like receptors (TLRs) at 50 μM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM.

Smiles

N(C=1N=C(C(OC)=O)N=C(N)N1)C2=CC=C(I)C=C2

Molecular Formula

C11H10IN5O2

Molecular Weight

371.13

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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CU-32

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