CU-32

CAT: 0931-MF-0096933-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0096933-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2400954-16-5
Target
Others|||cGAS
Related Pathways
Immunology/Inflammation|||Others
Bioactivity
CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50= 0.45 ?M) .1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective for cGAS over toll-like receptors (TLRs) at 50 ?M. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-? in THP-1 cells when used at concentrations of 10, 30, and 100 ?M.
Smiles
N(C=1N=C(C(OC)=O)N=C(N)N1)C2=CC=C(I)C=C2
Molecular Formula
C11H10IN5O2
Molecular Weight
371.13
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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