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CU-3

CAT: 0804-HY-121638Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-121638Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CU-3 is the racemate of (5Z,2E) -CU-3. (5Z,2E) -CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E) -CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E) -CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].
CAS Number
2983265-35-4
UNSPSC
12352005
Target
Apoptosis; DGK
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cu-3.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C(S/C1=C\C=C\C2=CC=CO2)=S)NS(=O)(C3=CC=CC=C3)=O
Molecular Formula
C16H12N2O4S3
Molecular Weight
392.47
References & Citations
[1]Liu K, et al. A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J Lipid Res. 2016 Mar;57 (3) :368-79.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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T27099-01CU-3
C8450-25(5Z,2E) -CU-3
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A21902-50(5Z,2E) -CU-3 50mg
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A21902-100(5Z,2E) -CU-3 100mg
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