CU-3

• Description :

  CU-3 is the racemate of (5Z,2E) -CU-3. (5Z,2E) -CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E) -CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E) -CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; DGK

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/cu-3.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1N(C(S/C1=C\C=C\C2=CC=CO2)=S)NS(=O)(C3=CC=CC=C3)=O

• Molecular Formula :

  C16H12N2O4S3

• Molecular Weight :

  392.47

• References & Citations :

  [1]Liu K, et al. A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J Lipid Res. 2016 Mar;57 (3) :368-79.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2983265-35-4]