CU-76

• UNSPSC Description:

  CU-76 is an inhibitor for human cyclic GMP-AMP synthase (hcGAS) with an IC50 of 0.24 μM. CU-76 selectively inhibits the DNA pathway in human cells, and can be used in autoimmune research[1].

• Target Antigen:

  Cyclic GMP-AMP Synthase

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/cu-76.html

• Smiles:

  O=C(C1=NC(N)=NC(NC2=CC(F)=C(I)C(F)=C2)=N1)OC

• Molecular Weight:

  407.11

• References & Citations:

  [1]Padilla-Salinas R, et al., Discovery of Small-Molecule Cyclic GMP-AMP Synthase Inhibitors. J Org Chem. 2020 Feb 7;85(3):1579-1600.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2400954-58-5