CU-76

• Description :

  CU-76 is an inhibitor for human cyclic GMP-AMP synthase (hcGAS) with an IC50 of 0.24 μM. CU-76 selectively inhibits the DNA pathway in human cells, and can be used in autoimmune research[1].

• UNSPSC :

  12352005

• Target :

  Cyclic GMP-AMP Synthase

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/cu-76.html

• Purity :

  97.6

• Smiles :

  O=C(C1=NC(N)=NC(NC2=CC(F)=C(I)C(F)=C2)=N1)OC

• Molecular Formula :

  C11H8F2IN5O2

• Molecular Weight :

  407.11

• References & Citations :

  [1]Padilla-Salinas R, et al., Discovery of Small-Molecule Cyclic GMP-AMP Synthase Inhibitors. J Org Chem. 2020 Feb 7;85 (3) :1579-1600.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2400954-58-5]