CU-CPT9b

• UNSPSC Description:

  CU-CPT9b is a specific TLR8 antagonist, with an IC50 of 0.7 nM. CU-CPT9b shows high binding affinity towards TLR8 with a Kd of 21 nM[1].

• Target Antigen:

  Toll-like Receptor (TLR)

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/CU-CPT-9b.html

• Purity:

  99.03

• Solubility:

  DMSO : 83.33 mg/mL (ultrasonic)

• Smiles:

  OC1=C(C)C=C(C=C1)C2=CC=NC3=CC(O)=CC=C32

• Molecular Weight:

  251.28

• References & Citations:

  [1]Zhang S, et al. Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat Chem Biol. 2018 Jan;14(1):58-64.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  2162962-69-6