PDE4-IN-5

PDE4-IN-5

• CAS Number: 2768626-06-6
• UNSPSC Description: PDE4-IN-5 (compound 33a) is a potent and selective PDE4 inhibitor (IC50=3.1 nM). PDE4-IN-5 has favorable skin permeability and a well-characterized binding mechanism. Anti-psoriasis effect[1].
• Target Antigen: Phosphodiesterase (PDE)
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/pde4-in-5.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1N(C2=NC(C)=CC=C2C3=C1[C@@H](C[C@@](C)(O3)CCO)/C=C(C)\C)CC
• Molecular Weight: 356.46
• References & Citations: [1]Song Z, et al. Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis. J Med Chem. 2022;65(5):4238-4254.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported