PDE4-IN-5

• Description :

  PDE4-IN-5 (compound 33a) is a potent and selective PDE4 inhibitor (IC50=3.1 nM) . PDE4-IN-5 has favorable skin permeability and a well-characterized binding mechanism. Anti-psoriasis effect[1].

• UNSPSC :

  12352005

• Target :

  Phosphodiesterase (PDE)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/pde4-in-5.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1N(C2=NC(C)=CC=C2C3=C1[C@@H](C[C@@](C)(O3)CCO)/C=C(C)\C)CC

• Molecular Formula :

  C21H28N2O3

• Molecular Weight :

  356.46

• References & Citations :

  [1]Song Z, et al. Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis. J Med Chem. 2022;65 (5) :4238-4254.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PDE4

• CAS Number :

  [2768626-06-6]