PDE4-IN-5

• UNSPSC Description:

  PDE4-IN-5 (compound 33a) is a potent and selective PDE4 inhibitor (IC50=3.1 nM). PDE4-IN-5 has favorable skin permeability and a well-characterized binding mechanism. Anti-psoriasis effect[1].

• Target Antigen:

  Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/pde4-in-5.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N(C2=NC(C)=CC=C2C3=C1[C@@H](C[C@@](C)(O3)CCO)/C=C(C)\C)CC

• Molecular Weight:

  356.46

• References & Citations:

  [1]Song Z, et al. Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis. J Med Chem. 2022;65(5):4238-4254.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2768626-06-6