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A2AAR/HDAC-IN-2

CAT: 0804-HY-143325Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-143325Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A2AAR/HDAC-IN-2 is a potent A2AAR/HDAC dual inhibitor, with good binding affinity for A2AAR (Ki=10.3 nM) and good inhibitory activity against HDAC1 (IC50=18.5 nM) . A2AAR/HDAC-IN-2 can be used in study of antitumor[1].
CAS Number
2767560-94-9
UNSPSC
12352005
Target
Adenosine Receptor; HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/a2aar-hdac-in-2.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(C2=CC=CO2)=C3C=NN(C3=N1)CC4=CC=CC(OCCCCCCC(NO)=O)=C4
Molecular Formula
C23H26N6O4
Molecular Weight
450.49
References & Citations
[1]Zhang J, et al. Dual-acting antitumor agents targeting the A2A adenosine receptor and histone deacetylases: Design and synthesis of 4- (furan-2-yl) -1H-pyrazolo[3,4-d]pyrimidin-6-amine derivatives. Eur J Med Chem. 2022 Jun 5;236:114326.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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