A2AAR/HDAC-IN-2

A2AAR/HDAC-IN-2

• CAS Number: 2767560-94-9
• UNSPSC Description: A2AAR/HDAC-IN-2 is a potent A2AAR/HDAC dual inhibitor, with good binding affinity for A2AAR (Ki=10.3 nM) and good inhibitory activity against HDAC1 (IC50=18.5 nM). A2AAR/HDAC-IN-2 can be used in study of antitumor[1].
• Target Antigen: Adenosine Receptor; HDAC
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics;GPCR/G Protein
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/a2aar-hdac-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: NC1=NC(C2=CC=CO2)=C3C=NN(C3=N1)CC4=CC=CC(OCCCCCCC(NO)=O)=C4
• Molecular Weight: 450.49
• References & Citations: [1]Zhang J, et al. Dual-acting antitumor agents targeting the A2A adenosine receptor and histone deacetylases: Design and synthesis of 4-(furan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine derivatives. Eur J Med Chem. 2022 Jun 5;236:114326.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported