A2AAR antagonist 5

• Description:

  A2AAR antagonist 5 is a selective A2AAR antagonist. A2AAR antagonist 5 inhibits NECA-stimulated adenylyl cyclase activity in hA2AAR-expressing CHO cells with an IC50 value of 1863 nM. A2AAR antagonist 5 possesses strong free radical scavenging activity, with an EC50 value of 22.21 μM in the DPPH assay. A2AAR antagonist 5 exerts notable neuroprotective effects in in vitro cerebral ischemia models. A2AAR antagonist 5 can be used for the study of cerebral ischemia[1].

• UNSPSC:

  12352005

• Target:

  Adenosine Receptor

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Neurological Disease

• Smiles:

  O=C (NC1=CC=C (C2=CN3C (C (N) =N2) =NN (C4=CC=CC=C4) C3=O) C=C1) CN5N=C (C) CC5=O

• Molecular Formula:

  C23H20N8O3

• Molecular Weight:

  456.46

• References & Citations:

  [1]Calenda S, et al. 8-Amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives hybridized with antioxidants: new highly potent and selective human A2A adenosine receptor antagonists as useful agents against cerebral ischemia. Bioorg Chem. 2025 Sep;164:108855.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Adenosine A1 receptor (A1R) ; Adenosine A2A receptor (A2AR) ; Adenosine A2B receptor (A2BR) ; Adenosine A3 receptor (A3R)