A2AAR antagonist 3

• Description:

  A2AAR antagonist 3 is a selective and potent A2A adenosine receptor (A2A AR) antagonist with an IC50 of 1.57 nM. A2AAR antagonist 3 demonstrates high and selective binding affinities to the A2A AR. A2AAR antagonist 3 demonstrates favorable stability in rat liver microsomes in vitro and acceptable pharmacokinetic profiles in vivo. A2AAR antagonist 3 can be used in cancer research[1].

• UNSPSC:

  12352005

• Target:

  Adenosine Receptor

• Related Pathways:

  GPCR/G Protein

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  OC (C) (C) C1=CC=CC (CN2N=NC (C3=NC (N) =NC4=C3C=CN4C) =C2) =N1

• Molecular Formula:

  C18H20N8O

• Molecular Weight:

  364.40

• References & Citations:

  [1]Li Z, et al. Design, synthesis, and biological evaluation of A2A adenosine receptor antagonists containing pyrrolo[2,3-d]pyrimidin-2-amine skeleton. Bioorg Chem. 2025 Jun 3;163:108664.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported