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Top/HDAC-IN-2

CAT: 0804-HY-145852Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145852Size:1 Each
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Description
Top/HDAC-IN-2 (45b), a Top and HDAC dual inhibitor, exhibits potent antitumor activities and induces apoptosis[1].
CAS Number
2775446-64-3
UNSPSC
12352005
Target
Apoptosis; HDAC; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/top-hdac-in-2.html
Solubility
10 mM in DMSO
Smiles
CN1C2=C(C(N3CCC4=C(C13)NC5=CC=C(C=C54)O)=O)C=C(C=C2)NCC6CCN(CC6)C7=NC=C(C=N7)C(NO)=O
Molecular Formula
C30H32N8O4
Molecular Weight
568.63
References & Citations
[1]Fugui Zhu, et al. Design, Synthesis, and Structure-Activity relationships of Evodiamine-Based topoisomerase (Top) /Histone deacetylase (HDAC) dual inhibitors. Bioorg Chem. 2022 May;122:105702.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3; HDAC6; HDAC8; Topo I; Topo II

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