LSD1/HDAC-IN-2

LSD1/HDAC-IN-2

• CAS Number: 2966782-82-9
• UNSPSC Description: LSD1/HDAC-IN-2 (Compound 20c) is the inhibitor for LSD and HDAC, that inhibits LSD1, HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, with IC50s of 39.0, 1.4, 1.0, 1.3, 2.9 and 16.0 nM, respectively. LSD1/HDAC-IN-2 inhibits the proliferation of cancer cells, especially the colorectal cancer cells. LSD1/HDAC-IN-2 arrests the cell cycle at G2/M phase, inhibits cell migration, and induces apoptosis in HCT-116 and HT-29 cells. LSD1/HDAC-IN-2 exhibits antitumor efficacy in mouse model without significant toxicity[1].
• Target Antigen: Apoptosis; HDAC; Histone Demethylase
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/lsd1-hdac-in-2.html
• Smiles: NC1=C(C)C(C2=CN(CCCCCCC(NO)=O)C3=C2C=C(C#N)C=C3)=CC=C1
• Molecular Weight: 390.48
• References & Citations: [1]Zhu HJ, et al., Discovery of Novel 5-Cyano-3-phenylindole-Based LSD1/HDAC Dual Inhibitors for Colorectal Cancer Treatment. J Med Chem. 2024 Nov 28;67(22):20172-20202.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported