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LSD1/HDAC-IN-2

CAT: 0804-HY-169938Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169938Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LSD1/HDAC-IN-2 (Compound 20c) is the inhibitor for LSD and HDAC, that inhibits LSD1, HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, with IC50s of 39.0, 1.4, 1.0, 1.3, 2.9 and 16.0 nM, respectively. LSD1/HDAC-IN-2 inhibits the proliferation of cancer cells, especially the colorectal cancer cells. LSD1/HDAC-IN-2 arrests the cell cycle at G2/M phase, inhibits cell migration, and induces apoptosis in HCT-116 and HT-29 cells. LSD1/HDAC-IN-2 exhibits antitumor efficacy in mouse model without significant toxicity[1].
CAS Number
2966782-82-9
UNSPSC
12352005
Target
Apoptosis; HDAC; Histone Demethylase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lsd1-hdac-in-2.html
Smiles
NC1=C(C)C(C2=CN(CCCCCCC(NO)=O)C3=C2C=C(C#N)C=C3)=CC=C1
Molecular Formula
C23H26N4O2
Molecular Weight
390.48
References & Citations
[1]Zhu HJ, et al., Discovery of Novel 5-Cyano-3-phenylindole-Based LSD1/HDAC Dual Inhibitors for Colorectal Cancer Treatment. J Med Chem. 2024 Nov 28;67 (22) :20172-20202.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3; HDAC6; HDAC8; KDM1/LSD1

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