Products for Research Use Only
RegisterLogin

CDK/HDAC-IN-2

CAT: 0804-HY-146276Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-146276Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CDK/HDAC-IN-2 is a potent HDAC/CDK dual inhibitor with IC50 of 6.4, 0.25, 45, >1000, 8.63, 0.30, >1000 nM for HDAC1, HDAC2, HDAC3, HDAC6,8, CDK1, CDK2, CDK4,6,7, respectively. CDK/HDAC-IN-2 shows excellent antiproliferative activities. CDK/HDAC-IN-2 induces apoptosis and cell cycle arrest at G2/M phase. CDK/HDAC-IN-2 shows potent antitumor efficacy[1].
CAS Number
2580938-58-3
UNSPSC
12352005
Target
Apoptosis; CDK; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk-hdac-in-2.html
Solubility
10 mM in DMSO
Smiles
NC1=CC=CC=C1NC(C2=CC=C(C=C2)CNC(C3=NNC=C3NC(C4=C(C=CC=C4Cl)Cl)=O)=O)=O
Molecular Formula
C25H20Cl2N6O3
Molecular Weight
523.37
References & Citations
[1]Cheng C, et al. Discovery of novel cyclin-dependent kinase (CDK) and histone deacetylase (HDAC) dual inhibitors with potent in vitro and in vivo anticancer activity. Eur J Med Chem. 2020 Mar 1;189:112073.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2; CDK4; CDK6; CDK7; HDAC1; HDAC2; HDAC3; HDAC6; HDAC8

Related Products

CatalogName
HY-132914CDK/HDAC-IN-1
HY-149819-01CDK/HDAC-IN-3
HY-169075CDK/HDAC-IN-4
HY-115585HDAC-IN-2
HY-13033-01CDK-IN-2
HY-145852Top/HDAC-IN-2
HY-169938LSD1/HDAC-IN-2
HY-155523Tubulin/HDAC-IN-2
HY-146159PI3K/HDAC-IN-2
HY-162828STAT3/HDAC-IN-2

Alternative Products

CatalogName
MBS5806332CDK/HDAC-IN-2
T61583-01CDK/HDAC-IN-1
T78906-01CDK/HDAC-IN-3
T200504-01CDK/HDAC-IN-4
MBS130849-01HDAC-IN-2
BUP12701-01CDK-IN-2
20R-1662HDAC 2 antibody
T203215-01LSD1/HDAC-IN-2
T64025-01Top/HDAC-IN-2
T62912-01PI3K/HDAC-IN-2

Popular Products