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A2AAR antagonist 2

CAT: 0804-HY-N12422-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N12422-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
3′-Methoxyfurano[4″,5″:3,4]chalcone (compound 2) is a selective A2AAR antagonist (IC50=33.5 nM) with high affinity. 3′-Methoxyfurano[4″,5″:3,4]chalcone is also a natural product obtained from the bark of Allium cepa L. 3′-Methoxyfurano[4″,5″:3,4]chalcone can promote T cell activation and can be used in cancer immunity research[1].
UNSPSC
12352005
Target
Adenosine Receptor
Type
Natural Products
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/a2aar-antagonist-2.html
Concentration
10mM
Purity
99.40
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(/C=C/C1=CC(C=CO2)=C2C=C1)C3=CC=CC(OC)=C3
Molecular Formula
C18H14O3
Molecular Weight
278.30
References & Citations
[1]Zhang RJ, et al. Exploring the Immunomodulatory Properties of Red Onion (Allium cepa L.) Skin: Isolation, Structural Elucidation, and Bioactivity Study of Novel Onion Chalcones Targeting the A2A Adenosine Receptor. J Agric Food Chem. 2023 Nov 6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Adenosine A2A receptor (A2AR)

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