A2AAR antagonist 4

• Description:

  A2AAR antagonist 4 is an orally active A2A Adenosine receptor antagonist with a Ki of 0.36 nM and a KB of 1 nM at hA2AAR. A2AAR antagonist 4 fully inhibits hA2AAR and hA2bAR at 10 μM. A2AAR antagonist 4 can be used for research of cancer, such as MC38 tiumor[1].

• UNSPSC:

  12352005

• Target:

  Adenosine Receptor

• Related Pathways:

  GPCR/G Protein

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  O[C@@H]1CCO[C@H]1N2C3=C(N=C2C4=CC=CO4)C(N)=NC(C#CCCCC)=N3

• Molecular Formula:

  C19H21N5O3

• Molecular Weight:

  367.40

• References & Citations:

  [1]Kim G, et al. Regio- and Stereoselective Ribose Modification in Truncated 2,8-Disubstituted Adenosine Scaffold to Develop Highly Potent A2AAdenosine Receptor Antagonists. J Med Chem. 2025 Aug 14;68 (15) :16802-16818.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Adenosine A1 receptor (A1R) ; Adenosine A2A receptor (A2AR) ; Adenosine A2B receptor (A2BR) ; Adenosine A3 receptor (A3R)