LSD1/HDAC-IN-2

CAT: 0931-MF-0112221-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0112221-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2966782-82-9
Target
Apoptosis|||Histone Demethylase|||HDAC
Related Pathways
DNA Damage/DNA Repair|||Apoptosis|||Chromatin/Epigenetic
Bioactivity
LSD1/HDAC-IN-2 (Compound 20c) acts as an inhibitor targeting both LSD1 and several HDACs, specifically HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, with IC50 values of 39.0, 1.4, 1.0, 1.3, 2.9, and 16.0 nM, respectively. This compound effectively inhibits the proliferation of cancer cells, notably colorectal cancer cells. LSD1/HDAC-IN-2 induces cell cycle arrest at the G2/M phase, inhibits cell migration, and triggers apoptosis in HCT-116 and HT-29 cells. Additionally, it demonstrates antitumor activity in mouse models without causing significant toxicity at a dose of 20 mg/kg.
Smiles
N#CC=1C=CC2=C(C1)C(=CN2CCCCCCC(=O)NO)C=3C=CC=C(N)C3C
Molecular Formula
C23H26N4O2
Molecular Weight
390.48
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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