A2AAR/HDAC-IN-1

A2AAR/HDAC-IN-1

• CAS Number: 2767560-51-8
• UNSPSC Description: A2AAR/HDAC-IN-1 (compound 14c) is an orally active, potent and balanced A2AAR/HDAC dual inhibitor, with a Ki of 163.5 nM for A2AAR and an IC50 of 145.3 nM for HDAC1. A2AAR/HDAC-IN-1 shows anticancer activity[1].
• Target Antigen: Adenosine Receptor; HDAC
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics;GPCR/G Protein
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/a2aar-hdac-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: NC1=CC=CC=C1NC(C2=CC=C(C=C2)CCN3N=CC4=C(N=C(N=C43)N)C5=CC=CO5)=O
• Molecular Weight: 439.47
• References & Citations: [1]Zhang J, et al. Dual-acting antitumor agents targeting the A2A adenosine receptor and histone deacetylases: Design and synthesis of 4-(furan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine derivatives. Eur J Med Chem. 2022 Jun 5;236:114326.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported