Nur77 modulator 3

• UNSPSC Description:

  Nur77 modulator 3 (9e) can bind to Nur77 and inhibit TGF-β1-induced α-SMA and COLA1 expression in a Nur77-dependent manner. Nur77 modulator 3 induces Nur77 expression and enhances autophagic flux by inhibiting the mTORC1 signaling pathway in vitro and in vivo. Nur77 modulator 3 blocks the progression of hepatic fibrosis[1].

• Target Antigen:

  Autophagy; mTOR

• Type:

  Reference compound

• Related Pathways:

  Autophagy;PI3K/Akt/mTOR

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/nur77-modulator-3.html

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  S=C(N/N=C/C1=CNC2=CC=CC=C12)NC3=CC=C(C)C=C3

• Molecular Weight:

  308.40

• References & Citations:

  [1]Lin G, et al. Identification of (E)-1-((1H-indol-3-yl)methylene)-4-substitute-thiosemicarbazones as potential anti-hepatic fibrosis agents. Bioorg Chem. 2023 Dec 16;143:107022.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported

• CAS Number:

  2097787-75-0