Nur77 modulator 3

• Description :

  Nur77 modulator 3 is a Nur77 modulator. Nur77 modulator 3 induces Nur77 expression, inhibits hepatic stellate cells (HSCs) activation, and reduces extracellular matrix (ECM) deposition. Nur77 modulator 3 enhances Nur77-denpendent autophagic flux and significantly inhibits the mTORC1 signaling pathway. Nur77 modulator 3 ameliorates HSCs activation, inflammation and hepatic fibrosis in vivo[1].

• UNSPSC :

  12352005

• Target :

  Atg8/LC3; Autophagy; mTOR; Nuclear Hormone Receptor 4A/NR4A; p62; TGF-beta/Smad

• Type :

  Reference compound

• Related Pathways :

  Autophagy; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad; Vitamin D Related/Nuclear Receptor

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Neurological Disease; Inflammation/Immunology; Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/nur77-modulator-3.html

• Purity :

  99.01

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  S=C(N/N=C/C1=CNC2=CC=CC=C12)NC3=CC=C(C)C=C3

• Molecular Formula :

  C17H16N4S

• Molecular Weight :

  308.40

• References & Citations :

  [1]Lin G, et al. Identification of (E) -1- ((1H-indol-3-yl) methylene) -4-substitute-thiosemicarbazones as potential anti-hepatic fibrosis agents. Bioorg Chem. 2023 Dec 16;143:107022.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MTORC1; Nur77/NR4A1

• CAS Number :

  [2097787-75-0]