Nur77 modulator 4

CAT: 0804-HY-170849Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-170849Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Nur77 modulator 4 (Compound 15h) is a Nur77 inducer with a KD of 0.477 μM. Nur77 modulator 4 significantly induces Nur77 expression and apoptosis, showing excellent growth inhibition in HepG2 and MCF-7 cells, with an IC50 of less than 5 μM. Nur77 modulator 4 activates Nur77-mediated ER stress through the PERK-ATF4 and IRE1 signaling pathways, thereby inducing cell apoptosis. Nur77 modulator 4 can be used in cancer research applications [1].
UNSPSC
12352005
Target
Apoptosis; IRE1; Nuclear Hormone Receptor 4A/NR4A; PERK
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
O=C(NNC(NC1=CC=CC=C1Cl)=O)NC2=CC3=C(NC(C45CC6CC(C5)CC(C6)C4)=C3)C=C2
Molecular Formula
C26H28ClN5O2
Molecular Weight
477.99
References & Citations
[1]Hu H, et al. Design, synthesis, and biological evaluation of N1- (2- (adamantan-1-yl) -1H-indol-5-yl) -N2- (substituent) -1,2-dicarboxamides as anticancer agents targeting Nur77-mediated endoplasmic reticulum stress. Bioorg Chem. 2025 Feb;155:108113.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nur77/NR4A1

Related Products

CatalogName
HY-131364-01Nur77 modulator 1
HY-162147-01Nur77 modulator 3
HY-115923Nur77 modulator 2
HY-148312Sirtuin modulator 4
HY-128831Kv3 modulator 4
HY-153681β-Catenin modulator-4
HY-148645STING modulator-4
HY-128581-01γ-Secretase modulator 4
HY-147530MGluR2 modulator 4
HY-173622PPARγ modulator-4

Alternative Products

CatalogName
MF-0121068-01Nur77 modulator 3
MF-0141521-01Nur77 modulator 2
MF-0113766-01Nur77 modulator 4
M28278-01Nur77 modulator 1
abx009165-01NUR77 (NUR77) Antibody
MBS125048-01Nur77
B1168-01Nur77 Antibody
AF4712-BPNUR77 Peptide
344813-01Nur77 discontinued
MBS611939-01Nak1 (Nur77)

Popular Products