Nur77 modulator 4

• Description:

  Nur77 modulator 4 (Compound 15h) is a Nur77 inducer with a KD of 0.477 μM. Nur77 modulator 4 significantly induces Nur77 expression and apoptosis, showing excellent growth inhibition in HepG2 and MCF-7 cells, with an IC50 of less than 5 μM. Nur77 modulator 4 activates Nur77-mediated ER stress through the PERK-ATF4 and IRE1 signaling pathways, thereby inducing cell apoptosis. Nur77 modulator 4 can be used in cancer research applications [1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; IRE1; Nuclear Hormone Receptor 4A/NR4A; PERK

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Vitamin D Related/Nuclear Receptor

• Field of Research:

  Cancer

• Smiles:

  O=C(NNC(NC1=CC=CC=C1Cl)=O)NC2=CC3=C(NC(C45CC6CC(C5)CC(C6)C4)=C3)C=C2

• Molecular Formula:

  C26H28ClN5O2

• Molecular Weight:

  477.99

• References & Citations:

  [1]Hu H, et al. Design, synthesis, and biological evaluation of N1- (2- (adamantan-1-yl) -1H-indol-5-yl) -N2- (substituent) -1,2-dicarboxamides as anticancer agents targeting Nur77-mediated endoplasmic reticulum stress. Bioorg Chem. 2025 Feb;155:108113.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Nur77/NR4A1