MRGPRX4 modulator-3

• Description:

  MRGPRX4 modulator-3 (Compound 1C) is a negative allosteric MAS-related G-protein-coupled receptor X4 (MRGPRX4) modulator. MRGPRX4 modulator-3 significantly attenuates Nateglinide (HY-B0422) (orthosteric agonist) -induced responses with an IC50 of 337 nM. MRGPRX4 modulator-3 can be used for chronic itch (especially cholestatic itch) and pain research[1].

• UNSPSC:

  12352100

• Target:

  Mas-related G-protein-coupled Receptor (MRGPR)

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Neurological Disease

• Smiles:

  C[C@]1 (C2 (C) C) /C (C[C@@H]2CC1) =N\NC3=NC (C4=CC=C (F) C=C4) =CS3

• Molecular Formula:

  C19H22FN3S

• Molecular Weight:

  343.46

• References & Citations:

  [1]Haider S, et al. Terpene-Based Thiazole Hydrazines as Negative Allosteric Modulators of MRGPRX4: In Vitro Evaluation and Binding Site Analysis[J]. ACS Medicinal Chemistry Letters, 2025.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported